A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation-Reference-Cited by-同舟云学术

A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation

Published:2013-07-25 Issue:4 Volume:122 Page:608-617
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Brancaleone Vincenzo¹,Gobbetti Thomas¹,Cenac Nicolas²,le Faouder Pauline²³,Colom Bartomeu¹,Flower Roderick J.¹,Vergnolle Nathalie²,Nourshargh Sussan¹,Perretti Mauro¹

Affiliation:

1. William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London, United Kingdom;

2. Université Paul Sabatier, Centre de Physiopathologie de Toulouse, Institut National de la Santé et de la Recherche Médicale U1043, Toulouse, France; and

3. Lipidomic Core Facility, Université Paul Sabatier, Toulouse, France

Abstract

Key Points Fpr2/3 activation controls platelet/neutrophil aggregates to afford LXA4 synthesis, thus inhibiting vascular inflammation on reperfusion. Aspirin can jumpstart this circuit by triggering 15-epi-lipoxin synthesis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/4/608/1373298/608.pdf

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