Glucocorticoid resistance is reverted by LCK inhibition in pediatric T-cell acute lymphoblastic leukemia-Reference-Cited by-同舟云学术

Glucocorticoid resistance is reverted by LCK inhibition in pediatric T-cell acute lymphoblastic leukemia

Published:2017-12-21 Issue:25 Volume:130 Page:2750-2761
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Serafin Valentina¹,Capuzzo Giorgia¹,Milani Gloria¹,Minuzzo Sonia Anna²,Pinazza Marica³,Bortolozzi Roberta¹,Bresolin Silvia¹,Porcù Elena¹,Frasson Chiara¹²³⁴,Indraccolo Stefano³,Basso Giuseppe¹,Accordi Benedetta¹

Affiliation:

1. Department of Woman’s and Child’s Health and

2. Immunology and Oncology Section, Department of Surgery, Oncology, and Gastroenterology, University of Padova, Padova, Italy;

3. Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IRCCS, Padova, Italy; and

4. Istituto di Ricerca Pediatrica Città della Speranza, Padova, Italy

Abstract

Key Points Resistance to glucocorticoid treatment in pediatric T-ALL can be reversed by LCK inhibitors in vitro and in vivo. IL-4 overexpression contributes to LCK-induced glucocorticoid resistance.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/25/2750/1404222/blood784603.pdf

Reference56 articles.

1. Long-term results of the Italian Association of Pediatric Hematology and Oncology (AIEOP) Studies 82, 87, 88, 91 and 95 for childhood acute lymphoblastic leukemia;Conter;Leukemia,2010

2. The effect of TLX3 expression on the prognosis of pediatric T cell acute lymphocytic leukemia—a systematic review;Ma;Tumour Biol,2014

3. Clinical features and outcome of SIL/TAL1-positive T-cell acute lymphoblastic leukemia in children and adolescents: a 10-year experience of the AIEOP group;D’Angiò;Haematologica,2015

4. Novel biological insights in T-cell acute lymphoblastic leukemia;Durinck;Exp Hematol,2015

5. Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP-BFM ALL 2000 study;Conter;Blood,2010

Cited by 51 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Transgenic αβ TCR tonic signaling is leukemogenic while strong stimulation is leukemia-suppressive;2024-01-22

2. Circadian rhythm-associated lncRNA RP11-414H17.5 as a key therapeutic target in osteosarcoma affects the tumor immune microenvironment and enhances malignancy;Journal of Orthopaedic Surgery and Research;2023-12-09

3. Proteomics in Childhood Acute Lymphoblastic Leukemia: Challenges and Opportunities;Diagnostics;2023-08-24

4. Five cuprotosis-related lncRNA signatures for prognosis prediction in acute myeloid leukaemia;Hematology;2023-07-07

5. Emerging Epigenetic and Posttranslational Mechanisms Controlling Resistance to Glucocorticoids in Acute Lymphoblastic Leukemia;HemaSphere;2023-06-22