CCND2 rearrangements are the most frequent genetic events in cyclin D1− mantle cell lymphoma

Author:

Salaverria Itziar12,Royo Cristina1,Carvajal-Cuenca Alejandra1,Clot Guillem1,Navarro Alba1,Valera Alejandra1,Song Joo Y.3,Woroniecka Renata4,Rymkiewicz Grzegorz5,Klapper Wolfram6,Hartmann Elena M.7,Sujobert Pierre8,Wlodarska Iwona9,Ferry Judith A.10,Gaulard Philippe8,Ott German11,Rosenwald Andreas7,Lopez-Guillermo Armando12,Quintanilla-Martinez Leticia13,Harris Nancy L.10,Jaffe Elaine S.3,Siebert Reiner2,Campo Elias1,Beà Sílvia1

Affiliation:

1. Department of Pathology, Hematopathology Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain;

2. Institute of Human Genetics, University Hospital Schleswig-Holstein Campus Kiel/Christian-Albrechts University, Kiel, Germany;

3. Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;

4. Cytogenetic Laboratory, and

5. Department of Pathology, The Maria Skłodowska-Curie Memorial Institute and Oncology Centre, Warsaw, Poland;

6. Department of Pathology, Hematopathology Section and Lymph Node Registry, Christian Albrechts University, Kiel, Germany;

7. Institute of Pathology, University of Würzburg, Würzburg, Germany;

8. Henri Mondor Hospital, Creteil, France;

9. Center for Human Genetics, KU Leuven, Leuven, Belgium;

10. Department of Pathology, Massachusetts General Hospital, Boston, MA;

11. Department of Clinical Pathology, Robert-Bosch-Krankenhaus, and Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany;

12. Department of Hematology, Hematopathology Unit, Hospital Clínic, Barcelona, Spain; and

13. Institute of Pathology, Eberhard-Karls-University of Tübingen, Tübingen, Germany

Abstract

Key Points This report describes a multidisciplinary study characterizing the largest series of cyclin D1− MCL patients. CCND2 translocations are the most frequent genetic event (55%) in cyclin D1− MCL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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