Validation and refinement of the Disease Risk Index for allogeneic stem cell transplantation

Author:

Armand Philippe1,Kim Haesook T.2,Logan Brent R.34,Wang Zhiwei3,Alyea Edwin P.1,Kalaycio Matt E.5,Maziarz Richard T.6,Antin Joseph H.1,Soiffer Robert J.1,Weisdorf Daniel J.7,Rizzo J. Douglas3,Horowitz Mary M.3,Saber Wael3

Affiliation:

1. Department of Medical Oncology and

2. Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston MA;

3. Center for International Blood and Marrow Transplant Research, Department of Medicine and

4. Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI;

5. Department of Hematologic Oncology and Blood Disorders, Cleveland Clinic, Cleveland, OH;

6. Center for Hematologic Malignancies, Knight Cancer Institute, Oregon Health & Science University, Portland, OR; and

7. Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN

Abstract

Key Points The DRI successfully stratified patients in a very large allogeneic transplantation registry cohort. The DRI was refined by using this cohort to build a more inclusive and conditioning intensity–independent index.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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