Interferon-γ impairs proliferation of hematopoietic stem cells in mice-Reference-Cited by-同舟云学术

Interferon-γ impairs proliferation of hematopoietic stem cells in mice

Published:2013-05-02 Issue:18 Volume:121 Page:3578-3585
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

de Bruin Alexander M.¹,Demirel Özlem²,Hooibrink Berend³,Brandts Christian H.²,Nolte Martijn A.¹⁴

Affiliation:

1. Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;

2. Department of Medicine, Hematology/Oncology, Goethe University, Frankfurt, Germany;

3. Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; and

4. Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Abstract

Key Points IFN-γ impairs maintenance of HSCs by directly reducing their proliferative capacity and impairing their restoration upon viral infection. IFN-γ induces SOCS1 expression in HSCs, which inhibits TPO-induced STAT5 phosphorylation, thereby deregulating key cell-cycle genes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/18/3578/1363468/3578.pdf

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5. Tumor necrosis factor (TNF) is a physiologic regulator of hematopoietic progenitor cells: increase of early hematopoietic progenitor cells in TNF receptor p55-deficient mice in vivo and potent inhibition of progenitor cell proliferation by TNF alpha in vitro.;Zhang;Blood,1995

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