Pathogenic role of B-cell receptor signaling and canonical NF-κB activation in mantle cell lymphoma

Author:

Saba Nakhle S.12,Liu Delong1,Herman Sarah E. M.1,Underbayev Chingiz1,Tian Xin3,Behrend David1,Weniger Marc A.1,Skarzynski Martin1,Gyamfi Jennifer1,Fontan Lorena4,Melnick Ari4ORCID,Grant Cliona5,Roschewski Mark5,Navarro Alba6,Beà Sílvia6,Pittaluga Stefania7,Dunleavy Kieron5,Wilson Wyndham H.5,Wiestner Adrian1

Affiliation:

1. Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;

2. Section of Hematology and Medical Oncology, Department of Medicine, Tulane University, New Orleans, LA;

3. Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;

4. Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY;

5. Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;

6. Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain; and

7. Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD

Abstract

Key PointsActivation of BCR and canonical NF-κB signaling in the lymph node correlates with survival in MCL. Mutations and polymorphisms in BCR and NF-κB pathways may confer cell autonomous signaling and affect response to ibrutinib.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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