Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients

Author:

Claushuis Theodora A. M.12,van Vught Lonneke A.12,Scicluna Brendon P.123,Wiewel Maryse A.12,Klein Klouwenberg Peter M. C.456,Hoogendijk Arie J.12,Ong David S. Y.456,Cremer Olaf L.4,Horn Janneke7,Franitza Marek89,Toliat Mohammad R.8,Nürnberg Peter8910,Zwinderman Aeilko H.3,Bonten Marc J.5,Schultz Marcus J.7,van der Poll Tom1211

Affiliation:

1. Center for Experimental and Molecular Medicine,

2. The Center for Infection and Immunity, and

3. Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;

4. Department of Intensive Care Medicine,

5. Department of Medical Microbiology, and

6. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands;

7. Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;

8. Cologne Center for Genomics,

9. Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, and

10. Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany; and

11. Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Abstract

Key Points Thrombocytopenia on intensive care unit admission is independently associated with increased mortality in patients with sepsis. Thrombocytopenia is associated with a more disturbed host response in critically ill patients with sepsis independent of disease severity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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