Lineage and species-specific long noncoding RNAs during erythro-megakaryocytic development

Author:

Paralkar Vikram R.1,Mishra Tejaswini23,Luan Jing4,Yao Yu4,Kossenkov Andrew V.5,Anderson Stacie M.6,Dunagin Margaret7,Pimkin Maxim4,Gore Meghneel8,Sun Diana4,Konuthula Neeraja9,Raj Arjun7,An Xiuli10,Mohandas Narla11,Bodine David M.12,Hardison Ross C.23,Weiss Mitchell J.4

Affiliation:

1. Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;

2. Center for Comparative Genomics and Bioinformatics, and

3. Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA;

4. Division of Hematology, The Children’s Hospital of Philadelphia, Philadelphia, PA;

5. Center for Systems and Computational Biology, The Wistar Institute, Philadelphia, PA;

6. National Human Genome Research Institute Flow Cytometry Core Facility, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD;

7. Department of Bioengineering, University of Pennsylvania, Philadelphia, PA;

8. Salesforce, San Francisco, CA;

9. Icahn School of Medicine at Mount Sinai, New York, NY;

10. Laboratory of Membrane Biology, and

11. Red Cell Physiology Laboratory, New York Blood Center, New York, NY; and

12. Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD

Abstract

Key Points Hundreds of lineage-specific lncRNAs are expressed during mouse and human erythropoiesis. Most mouse erythroid lncRNAs are not expressed in human erythroblasts and vice versa, yet some appear to be functional.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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