How I treat influenza in patients with hematologic malignancies

Author:

Casper Corey12345,Englund Janet6,Boeckh Michael13

Affiliation:

1. Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA;

2. Infection Control Program, Seattle Cancer Care Alliance, WA;

3. Departments ofMedicine,

4. Epidemiology, and

5. Global Health, University of Washington, Seattle; and

6. Seattle Children's Hospital Research Institute, WA

Abstract

Abstract The 2009 H1N1 influenza pandemic has heightened the interest of clinicians for options in the prevention and management of influenza virus infection in immunocompromised patients. Even before the emergence of the novel 2009 H1N1 strain, influenza disease was a serious complication in patients with hematologic malignancies receiving chemotherapy or undergoing hematopoietic cell transplantation. Here we review the clinical manifestations of seasonal and 2009 H1N1 influenza and discuss current diagnosis, antiviral treatment, and prophylaxis options. We also summarize infection control and vaccination strategies for patients, family members, and caregivers.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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