Serum free light chains, not urine specimens, should be used to evaluate response in light-chain multiple myeloma-Reference-Cited by-同舟云学术

Serum free light chains, not urine specimens, should be used to evaluate response in light-chain multiple myeloma

Published:2016-12-22 Issue:25 Volume:128 Page:2941-2948
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Dejoie Thomas¹,Corre Jill²,Caillon Helene¹,Hulin Cyrille³,Perrot Aurore⁴,Caillot Denis⁵,Boyle Eileen⁶,Chretien Marie-Lorraine⁵,Fontan Jean⁷,Belhadj Karim⁸,Brechignac Sabine⁹,Decaux Olivier¹⁰,Voillat Laurent¹¹,Rodon Philippe¹²,Fitoussi Olivier¹³,Araujo Carla¹⁴,Benboubker Lotfi¹⁵,Fontan Charlotte²,Tiab Mourad¹⁶,Godmer Pascal¹⁷,Luycx Odile¹⁸,Allangba Olivier¹⁹,Pignon Jean-Michel²⁰,Fuzibet Jean-Gabriel²¹,Legros Laurence²¹,Stoppa Anne Marie²²,Dib Mamoun²³,Pegourie Brigitte²⁴,Orsini-Piocelle Frederique²⁵,Karlin Lionel²⁶,Arnulf Bertrand²⁷,Roussel Murielle²,Garderet Laurent²⁸,Mohty Mohamad²⁸,Meuleman Nathalie²⁹,Doyen Chantal³⁰,Lenain Pascal³¹,Macro Margaret³²,Leleu Xavier³³,Facon Thierry⁶,Moreau Philippe¹,Attal Michel²,Avet-Loiseau Herve²

Affiliation:

1. Biochemistry Laboratory and Hematology Department, Centre Hospitalier Universitaire (CHU), Nantes, France;

2. Institut Universitaire du Cancer, CHU, Centre de Recherche en Cancérologie de Toulouse, INSERM 1037, Toulouse, France;

3. Hematology Department, CHU, Bordeaux, France;

4. Hematology Department, CHU, Nancy, France;

5. Hematology Department, CHU, Dijon, France;

6. Hematology Department, CHU, Lille, France;

7. Hematology Department, CHU, Besancon, France;

8. Hematology Department, CHU, Creteil, France;

9. Hematology Department, CHU, Bobigny, France;

10. Internal Medicine, CHU, Rennes, France;

11. Centre Hospitalier William Morey, Departmental Hospital, Chalon, France;

12. Clinical Research Unit, Centre Hospitalier de Périgueux, Departmental Hospital, Perigueux, France;

13. Hematology Department, Polyclinique Bordeaux-Nord, Bordeaux, France;

14. Centre Hospitalier Departemental, Bayonne, France;

15. Hôpital Bretonneau, CHU, Tours, France;

16. Centre Hospitalier Departemental, La Roche sur Yon, La Roche/Yon, France;

17. Centre Hospitalier Departemental, Vannes, France;

18. Centre Hospitalier Departemental, Lorient, France;

19. Centre Hospitalier Departemental, Saint-Brieuc, France;

20. Centre Hospitalier Departemental, Dunkerque, France;

21. Internal Medicine, CHU, Nice, France;

22. Hematology Department, Institut Paoli Calmette, Marseille, France;

23. Hematology Department, CHU, Angers, France;

24. Hematology Department, CHU, Grenoble, France;

25. Hematology Department, Centre Hospitalier Departemental, Annecy, France;

26. Hematology Department, CHU, Lyon, France;

27. Immunopathology Service, Saint-Louis University Hospital, Paris, France;

28. Hematology Department, Saint-Antoine University Hospital, Paris, France;

29. Department of Clinical and Experimental Hematology, Jules Bordet Institute, Brussels, Belgium;

30. Department of Clinical and Experimental Research, Clinique Universitaire Mont-Godinne, Yvoir, Belgium;

31. Hematology Department, Centre Henri Becquerel, Rouen, France;

32. Hematology Department, CHU, Caen, France; and

33. Hematology Department, CHU, Poitiers, France

Abstract

Key PointsSerum FLC analysis is a more sensitive indicator of disease than urinalysis. Improved sensitivity of serum over urine measurements during monitoring translates into valuable prognostic information.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/25/2941/1397233/blood726778.pdf

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3. Extended use of serum free light chain as a biomarker in lymphoproliferative disorders: a comprehensive review;Charafeddine;Am J Clin Pathol,2012

4. The evolving use of serum free light chain assays in haematology;Pratt;Br J Haematol,2008

5. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma;Rajkumar;Lancet Oncol,2014

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