A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma

Author:

Salaverria Itziar12,Martin-Guerrero Idoia13,Wagener Rabea1,Kreuz Markus4,Kohler Christian W.5,Richter Julia1,Pienkowska-Grela Barbara6,Adam Patrick7,Burkhardt Birgit8,Claviez Alexander9,Damm-Welk Christine10,Drexler Hans G.11,Hummel Michael12,Jaffe Elaine S.13,Küppers Ralf14,Lefebvre Christine15,Lisfeld Jasmin10,Löffler Markus4,Macleod Roderick A. F.11,Nagel Inga1,Oschlies Ilske16,Rosolowski Maciej4,Russell Robert B.17,Rymkiewicz Grzegorz18,Schindler Detlev19,Schlesner Matthias20,Scholtysik René14,Schwaenen Carsten21,Spang Rainer5,Szczepanowski Monika16,Trümper Lorenz22,Vater Inga1,Wessendorf Swen21,Klapper Wolfram16,Siebert Reiner1

Affiliation:

1. Institute of Human Genetics, University Hospital Schleswig-Holstein, Campus Kiel/Christian-Albrechts University, Kiel, Germany;

2. Department of Pathology, Hematopathology Unit, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain;

3. Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (Universidad del País Vasco/Euskal Herriko Univertsitatea), Leioa, Spain;

4. Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany;

5. Institute of Functional Genomics, University of Regensburg, Germany;

6. Department of Pathology, Cytogenetic Laboratory, The Maria Skłodowska-Curie Memorial Institute and Oncology Centre, Warsaw, Poland;

7. Institute of Pathology, University of Tübingen, Tübingen, Germany;

8. Non-Hodgkin Lymphoma–Berlin-Frankfurt-Münster Study Center and Department of Pediatric Hematology and Oncology, University Children’s Hospital, Münster, Germany;

9. Department of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel/Christian-Albrechts University, Kiel, Germany;

10. Non-Hodgkin Lymphoma–Berlin-Frankfurt-Münster Study Center and Department of Pediatric Hematology and Oncology, Justus-Liebig University, Giessen, Germany;

11. Leibniz-Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany;

12. Institute of Pathology, Campus Benjamin Franklin, Charité–Universitäts-Medizin Berlin, Berlin, Germany;

13. Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;

14. Institute of Cell Biology (Cancer Research), Medical School, University of Duisburg-Essen, Essen, Germany;

15. Department of Hematology, Onco-Genetics, and Immunology, Institute of Biology and Pathology, Grenoble, France;

16. Department of Pathology, Hematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein, Campus Kiel/Christian-Albrechts University, Kiel, Germany;

17. CellNetworks Cluster of Excellence, University of Heidelberg, Heidelberg, Germany;

18. Department of Pathology, Flow Cytometry Laboratory, The Maria Sk\x{0142}odowska-Curie Memorial Institute and Oncology Centre, Warsaw, Poland;

19. Department of Human Genetics, Biocenter, University of Wuerzburg, Wuerzburg, Germany;

20. Division Theoretical Bioinformatics, Deutsches Krebsforschungszentrum Heidelberg (DKFZ), Heidelberg, Germany;

21. Klinikum Esslingen, Esslingen, Germany; and

22. Department of Hematology and Oncology, Georg-August University of Göttingen, Germany

Abstract

Key Points A subset of lymphomas with gene expression and pathological characteristics of Burkitt lymphomas but absence of MYC translocation does exist. These lymphomas carry chr 11q proximal gains and telomeric losses, suggesting co-deregulation of oncogenes and tumor suppressor genes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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