Phase 3 study of nilotinib vs imatinib in Chinese patients with newly diagnosed chronic myeloid leukemia in chronic phase: ENESTchina

Author:

Wang Jianxiang1,Shen Zhi-Xiang2,Saglio Giuseppe3,Jin Jie4,Huang He4,Hu Yu5,Du Xin6,Li Jianyong7,Meng Fanyi8,Zhu Huanling9,Hu Jianda10,Wang Jianmin11,Hou Ming12,Hertle Sabine13,Menssen Hans D.13,Ortmann Christine-Elke13,Tribouley Catherine14,Yuan Ye15,Baccarani Michele16,Huang Xiaojun17

Affiliation:

1. State Key Laboratory of Experimental Hematology, Department of Clinical Hematology, Institute of Hematology, Chinese Academy of Medical Sciences, Tianjin, China;

2. Shanghai Institute of Hematology, Shanghai Ruijin Hospital, Shanghai, China;

3. Department of Clinical and Biological Sciences, San Luigi Hospital, University of Turin, Orbassano, Italy;

4. Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, Zhejiang Province, China;

5. Institute of Hematology, Wuhan Union Hospital, Tongji Medical College, Wuhan Hubei, China;

6. Department of Hematology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou Guangdong, China;

7. Department of Hematology, Jiangsu Province People’s Hospital, Nan Jing, China;

8. Department of Hematology, Nanfang Hospital, Guangzhou Southern Medical University, Guangzhou Guangdong, China;

9. Department of Hematology, West China Hospital of Sichuan University, Chengdu Sichuan, China;

10. Department of Hematology, Fujian Medical University Union Hospital, Fuzhou, China;

11. Department of Hematology, Changhai Hospital, The Second Military Medical University, Shanghai, China;

12. Department of Hematology, Qilu Hospital, Shandong University, Jinan, China;

13. Novartis Pharma AG, Basel, Switzerland;

14. Novartis Pharmaceuticals Corporation, East Hanover, NJ;

15. Beijing Novartis Pharma Company, Limited, Beijing, China;

16. Department of Hematology-Oncology, and the Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna, Bologna, Italy; and

17. Peking University People’s Hospital and Institute of Hematology, Beijing, China

Abstract

Key Points Chinese patients with newly diagnosed CML-CP achieved higher rates of MMR with nilotinib vs imatinib. Nilotinib was well tolerated, and no new safety signals were observed.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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