IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells-Reference-Cited by-同舟云学术

IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells

Published:2015-05-14 Issue:20 Volume:125 Page:3144-3152
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Schinke Carolina¹,Giricz Orsolya¹,Li Weijuan¹,Shastri Aditi¹,Gordon Shanisha¹,Barreyro Laura¹,Bhagat Tushar¹,Bhattacharyya Sanchari¹,Ramachandra Nandini¹,Bartenstein Matthias¹,Pellagatti Andrea²,Boultwood Jacqueline²,Wickrema Amittha³,Yu Yiting¹,Will Britta¹,Wei Sheng⁴,Steidl Ulrich¹,Verma Amit¹

Affiliation:

1. Division of Hemato-Oncology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY;

2. Leukemia and Lymphoma Research Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, John Radcliffe Hospital, and National Institute for Health Research Biomedical Research Centre, Oxford, United Kingdom;

3. Department of Medicine, Hematology-Oncology, Cancer Research Center, University of Chicago, Chicago, IL; and

4. Department of Immunology, Clinical Immunology, Moffitt Cancer Center, Tampa, FL

Abstract

Key Points IL8-CXCR2 is overexpressed in purified stem cells from AML and MDS, and CXCR2 expression is associated with worse prognosis. Inhibition of CXCR2 by genetic and pharmacologic means leads to decreased viability in AML/MDS stem cells and in vitro and in vivo models.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/20/3144/1386056/3144.pdf

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