PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia-Reference-Cited by-同舟云学术

PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia

Published:2015-07-09 Issue:2 Volume:126 Page:203-211
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

McClanahan Fabienne¹²,Hanna Bola²,Miller Shaun¹,Clear Andrew James¹,Lichter Peter²,Gribben John G.¹,Seiffert Martina²

Affiliation:

1. Centre for Haemato-Oncology, Barts Cancer Institute, London, United Kingdom; and

2. Molecular Genetics, German Cancer Research Center, Heidelberg, Germany

Abstract

Key Points In vivo PD-L1 blockade prevents CLL development in the Eµ-TCL1 adoptive transfer model. In vivo PD-L1 blockade normalizes T-cell and myeloid cell populations and immune effector functions.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/2/203/1389886/203.pdf

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