A systematic review of transfusion-associated graft-versus-host disease

Author:

Kopolovic Ilana1,Ostro Jackie1,Tsubota Hideki2,Lin Yulia34,Cserti-Gazdewich Christine M.5ORCID,Messner Hans A.6,Keir Amy K.7,DenHollander Neal8,Dzik Walter S.9,Callum Jeannie34

Affiliation:

1. Department of Medicine, Division of Hematology, and

2. Division of Cardiac Surgery, University of Toronto, Toronto, ON, Canada;

3. Department of Clinical Pathology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada;

4. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada;

5. Department of Laboratory Medicine, University Health Network, University of Toronto, Toronto, ON, Canada;

6. Allogeneic Blood and Marrow Transplant Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada;

7. Robinson Institute, University of Adelaide, Adelaide, South Australia;

8. Regional Histocompatibility Laboratory, University Health Network, Toronto, ON, Canada; and

9. Blood Transfusion Service, Massachusetts General Hospital, Boston, MA

Abstract

Key Points Fifty percent of TA-GVHD cases occur in patients who would not be predicted to be at risk for TA-GVHD by current guidelines for blood irradiation. Donor lymphocytes whose HLA antigens are all shared by the recipient dominate in TA-GVHD cases, particularly in immune-competent recipients.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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