Leukemic marrow infiltration reveals a novel role for Egr3 as a potent inhibitor of normal hematopoietic stem cell proliferation-Reference-Cited by-同舟云学术

Leukemic marrow infiltration reveals a novel role for Egr3 as a potent inhibitor of normal hematopoietic stem cell proliferation

Published:2015-09-10 Issue:11 Volume:126 Page:1302-1313
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Cheng Hui¹²,Hao Sha¹,Liu Yanfeng¹,Pang Yakun¹,Ma Shihui¹,Dong Fang¹,Xu Jing¹,Zheng Guoguang¹,Li Shaoguang³,Yuan Weiping¹²⁴,Cheng Tao¹²⁴

Affiliation:

1. State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Collaborative Innovation Center for Cancer Medicine, Tianjin, China;

2. Center for Stem Cell Medicine, Chinese Academy of Medical Sciences, Tianjin, China;

3. Division of Hematology/Oncology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA; and

4. Department of Stem Cell and Regenerative Medicine, Peking Union Medical College, Tianjin, China

Abstract

Key Points Increased quiescence of HSCs and HPCs in leukemogenesis, and reversible suppression of HSCs was observed in leukemic bone marrow. A novel inhibitory role of Egr3 in HSC proliferation was revealed by leukemic infiltration in bone marrow.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/11/1302/1387839/1302.pdf

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