Identification of key lipids critical for platelet activation by comprehensive analysis of the platelet lipidome

Author:

Peng Bing1ORCID,Geue Sascha2,Coman Cristina1ORCID,Münzer Patrick2,Kopczynski Dominik1ORCID,Has Canan1ORCID,Hoffmann Nils1ORCID,Manke Mailin-Christin2,Lang Florian3,Sickmann Albert145,Gawaz Meinrad2,Borst Oliver2,Ahrends Robert1ORCID

Affiliation:

1. Leibniz-Institut für Analytische Wissenschaften–ISAS–e.V., Dortmund, Germany;

2. Department of Cardiology and Cardiovascular Medicine and

3. Department of Physiology, University of Tübingen, Tübingen, Germany;

4. Medizinische Fakultät, Ruhr-Universität Bochum, Bochum, Germany; and

5. College of Physical Sciences, University of Aberdeen, Old Aberdeen, United Kingdom

Abstract

Key Points First quantitative analysis of dynamic platelet lipidome modulation reveals key lipids altered in platelet activation. Lipidomics in a knockout approach unravel SMPD1 as a powerful modulator of platelet lipidome and activation via regulation of SPC.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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