miR-21 mediates hematopoietic suppression in MDS by activating TGF-β signaling-Reference-Cited by-同舟云学术

miR-21 mediates hematopoietic suppression in MDS by activating TGF-β signaling

Published:2013-04-11 Issue:15 Volume:121 Page:2875-2881
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Bhagat Tushar D.¹,Zhou Li¹,Sokol Lubomir²,Kessel Rachel¹,Caceres Gisela²,Gundabolu Krishna¹,Tamari Roni¹,Gordon Shanisha¹,Mantzaris Ioannis¹,Jodlowski Tomasz¹,Yu Yiting¹,Jing Xiaohong¹,Polineni Rahul¹,Bhatia Kavi¹,Pellagatti Andrea³,Boultwood Jacqueline³,Kambhampati Suman⁴,Steidl Ulrich¹,Stein Cy¹,Ju Wenjun⁵,Liu Gang⁶,Kenny Paraic¹,List Alan²,Bitzer Markus¹⁵,Verma Amit¹

Affiliation:

1. Albert Einstein College of Medicine, Bronx, NY;

2. Moffitt Cancer Center, Tampa, FL;

3. LLR Molecular Haematology Unit, NDCLS, John Radcliffe Hospital, Oxford, UK;

4. VA Medical Center/University of Kansas Medical Center, Kansas City, MO;

5. University of Michigan, Ann Arbor, MI; and

6. University of Alabama, Birmingham, AL

Abstract

Key PointsWe observed that SMAD7, a negative regulator of TGF-β receptor-I kinase, is markedly reduced in MDS, and leads to ineffective hematopoiesis. Increased levels of microRNA-21 are seen in MDS and reduce SMAD7 levels, thus overactivating TGF-β signaling.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/15/2875/1365431/2875.pdf

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