PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome-Reference-Cited by-同舟云学术

PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome

Published:2015-08-27 Issue:9 Volume:126 Page:1118-1127
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Pandolfi Ashley¹,Stanley Robert F.¹,Yu Yiting¹,Bartholdy Boris¹,Pendurti Gopichand¹,Gritsman Kira¹,Boultwood Jacqueline²,Chernoff Jonathan³,Verma Amit¹,Steidl Ulrich¹

Affiliation:

1. Departments of Cell Biology and of Medicine, Division of Hemato-Oncology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY;

2. Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom; and

3. Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA

Abstract

Key Points Targeting of PAK1 inhibits primary AML and MDS patients' cells including leukemia stem cells but spares healthy stem and progenitor cells. Inhibition of PAK1 induces differentiation and apoptosis of AML cells through downregulation of MYC and a core network of MYC target genes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/9/1118/1391761/1118.pdf

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