Geriatric assessment predicts survival and toxicities in elderly myeloma patients: an International Myeloma Working Group report

Author:

Palumbo Antonio1,Bringhen Sara1,Mateos Maria-Victoria2,Larocca Alessandra1,Facon Thierry3,Kumar Shaji K.4,Offidani Massimo5,McCarthy Philip6,Evangelista Andrea7,Lonial Sagar8,Zweegman Sonja9,Musto Pellegrino10,Terpos Evangelos11,Belch Andrew12,Hajek Roman13,Ludwig Heinz14,Stewart A. Keith15,Moreau Philippe16,Anderson Kenneth17,Einsele Hermann18,Durie Brian G. M.19,Dimopoulos Meletios A.11,Landgren Ola20,San Miguel Jesus F.21,Richardson Paul22,Sonneveld Pieter23,Rajkumar S. Vincent4

Affiliation:

1. Myeloma Unit, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Italy;

2. Servicio de Hematología, Hospital Universitario de Salamanca, Centro de Investigación del Cáncer, Instituto de Biología Molecular y Celular del Cáncer, Universidad de Salamanca–Centro Superior de Investigaciones Científicas, Salamanca, Spain;

3. Department of Hematology, University Hospital, Lille, France;

4. Division of Hematology, College of Medicine, Mayo Clinic, Rochester, MN;

5. Clinica di Ematologia, Azienda Ospedaliero-Universitaria Ospedali Riuniti di Ancona, Ancona, Italy;

6. Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY;

7. Unit of Clinical Epidemiology, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Italy;

8. Department of Hematology and Medical Oncology, Emory University, Atlanta, GA;

9. Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands;

10. Scientific Direction, Istituto di Ricovero e Cura a Carattere Scientifico, Referral Cancer Center of Basilicata, Rionero in Vulture, Italy;

11. Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece;

12. Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, AB, Canada;

13. Department of Haematooncology and Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic;

14. Department of Oncology, Hematology and Palliative Care, Wilhelminen, Vienna, Austria;

15. Division of Hematology-Oncology, Mayo Clinic, Scottsdale, AZ;

16. Department of Hematology, University Hospital Hôtel-Dieu, Nantes, France;

17. Department of Hematology/Oncology, Dana-Farber Cancer Institute, Boston, MA;

18. Medical Clinic and Polyclinic II, Department of Internal Medicine II, University Hospital, Wuerzburg, Germany;

19. Department of Hematology/Oncology, Cedars-Sinai Comprehensive Cancer Center, Los Angeles, CA;

20. Multiple Myeloma section, National Cancer Institute, Bethesda, MD;

21. Clínica Universidad de Navarra, Centro de Investigaciones Médicas Aplicadas, Pamplona, Spain;

22. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA; and

23. Department of Hematology, Erasmus Medical Center and HOVON Data Center, Rotterdam, The Netherlands

Abstract

Key Points Elderly patients with myeloma are heterogeneous and assessment strategies are needed to define the frailty profile. The proposed frailty score aims to better assess patients and provide them with more suitable therapies.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference37 articles.

1. Multiple myeloma.;Palumbo;N Engl J Med,2011

2. Altekruse SF Kosary CL Krapcho M SEER Cancer Statistics Review, 1975-2007. National Cancer Institute, Bethesda, MD. http://seer.cancer.gov/csr/1975_2007/. Accessed June 3, 2014

3. Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma.;San Miguel;N Engl J Med,2008

4. Thalidomide for previously untreated elderly patients with multiple myeloma: meta-analysis of 1685 individual patient data from 6 randomized clinical trials.;Fayers;Blood,2011

5. Continuous lenalidomide treatment for newly diagnosed multiple myeloma.;Palumbo;N Engl J Med,2012

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