Utility of baseline 18FDG-PET/CT functional parameters in defining prognosis of primary mediastinal (thymic) large B-cell lymphoma

Author:

Ceriani Luca1,Martelli Maurizio2,Zinzani Pier Luigi3,Ferreri Andrés J. M.4,Botto Barbara5,Stelitano Caterina6,Gotti Manuel7,Cabras Maria Giuseppina8,Rigacci Luigi9,Gargantini Livio10,Merli Francesco11,Pinotti Graziella12,Mannina Donato13,Luminari Stefano14ORCID,Stathis Anastasios1,Russo Eleonora2,Cavalli Franco1,Giovanella Luca1,Johnson Peter W. M.15,Zucca Emanuele1

Affiliation:

1. Oncology Institute of Southern Switzerland, Bellinzona, Switzerland;

2. Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy;

3. Institute of Hematology and Medical Oncology, Policlinico S. Orsola-Malpighi, Bologna, Italy;

4. Department of Oncology, Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy;

5. Hematology, Azienda Ospedaliera Città della Salute e della Scienza, Turin, Italy;

6. Hematology, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria, Italy;

7. Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy;

8. Hematology, Ospedale Businco, Cagliari, Italy;

9. Hematology, Policlinico Careggi, Florence, Italy;

10. Department of Hematology, Niguarda Ca' Granda Hospital, Milan, Italy;

11. Hematology Unit, Department of Oncology, Azienda Ospedaliera ASMN IRCCS Reggio Emilia, Italy;

12. Medical Oncology Unit, Ospedale di Circolo Fondazione Macchi, Varese, Italy;

13. Department of Hematology, Azienda Ospedaliera Papardo, Messina, Italy;

14. Onco-Hematology Department, Modena University, Modena, Italy; and

15. Cancer Research UK Centre, University of Southampton, Southampton, United Kingdom

Abstract

Key Points 18FDG PET/CT is a very important staging tool for patients with PMBCL. Metabolic activity defined by TLG on the baseline PET scan is a powerful predictor of PMBCL outcome.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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