Notch signals are required for in vitro but not in vivo maintenance of human hematopoietic stem cells and delay the appearance of multipotent progenitors-Reference-Cited by-同舟云学术

Notch signals are required for in vitro but not in vivo maintenance of human hematopoietic stem cells and delay the appearance of multipotent progenitors

Published:2014-02-20 Issue:8 Volume:123 Page:1167-1177
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Benveniste Patricia¹²,Serra Pablo¹²,Dervovic Dzana¹²,Herer Elaine³,Knowles Gisele²,Mohtashami Mahmood¹²,Zúñiga-Pflücker Juan Carlos¹²

Affiliation:

1. Department of Immunology, University of Toronto, Toronto, ON, Canada;

2. Sunnybrook Research Institute, Toronto, ON, Canada; and

3. Women and Babies Program, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Abstract

Key Points Notch signals expand human HSC (CD90low) cells in vitro and delay the expansion of CD45RAint and CD45RAhi cells in vitro. HSCs expanded in vitro are equal to ex vivo CD90low cells in immune reconstitution.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/8/1167/1378748/1167.pdf

Reference37 articles.

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4. CD34(-) cells at the apex of the human hematopoietic stem cell hierarchy have distinctive cellular and molecular signatures.;Anjos-Afonso;Cell Stem Cell,2013

5. Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells.;Maillard;Cell Stem Cell,2008

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