Final analysis of survival outcomes in the phase 3 FIRST trial of up-front treatment for multiple myeloma

Author:

Facon Thierry1,Dimopoulos Meletios A.2,Dispenzieri Angela3,Catalano John V.4,Belch Andrew5,Cavo Michele6,Pinto Antonello7,Weisel Katja8,Ludwig Heinz9,Bahlis Nizar J.10,Banos Anne11,Tiab Mourad12,Delforge Michel13,Cavenagh Jamie D.14,Geraldes Catarina15,Lee Je-Jung16,Chen Christine17,Oriol Albert18,De La Rubia Javier19,White Darrell20,Binder Daniel21,Lu Jin22,Anderson Kenneth C.23,Moreau Philippe24,Attal Michel25,Perrot Aurore26,Arnulf Bertrand27,Qiu Lugui28,Roussel Murielle29,Boyle Eileen1,Manier Salomon1,Mohty Mohamad30,Avet-Loiseau Herve31,Leleu Xavier32,Ervin-Haynes Annette33,Chen Guang33,Houck Vanessa33,Benboubker Lotfi34,Hulin Cyrille35

Affiliation:

1. Service des Maladies du Sang, Hôpital Claude Huriez, Lille, France;

2. Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Athens, Greece;

3. Mayo Clinic, Rochester, MN;

4. Frankston Hospital and Monash University, Frankston, Australia;

5. Cross Cancer Institute, Edmonton, Canada;

6. Seragnoli Institute of Hematology, Bologna University School of Medicine, Bologna, Italy;

7. Department of Hematology and Developmental Therapeutics, Hematology/Oncology and Stem Cells Transplantation Unit, National Cancer Institute, Fondazione “Pascale,” Naples, Italy;

8. Department of Hematology, University of Tuebingen, Tuebingen, Germany;

9. Wilhelminenspital, Center for Oncology, Vienna, Austria;

10. Southern Alberta Cancer Research Institute, University of Calgary, Calgary, Canada;

11. Centre Hospitalier de la Côte Basque, Bayonne, France;

12. Department of Hematology, University Hospital, La Roche Sur Yon, France;

13. University Hospital Leuven, Leuven, Belgium;

14. Barts Health National Health Service Trust, London, United Kingdom;

15. Hospitais da Universidade de Coimbra, Coimbra, Portugal;

16. Chonnam National University Hwasun Hospital, Jeollanamdo, South Korea;

17. Princess Margaret Hospital, Toronto, Canada;

18. Institut Català d’Oncologia and Institut Josep Carreras, Hospital Germans Trias i Pujol, Badalona, Spain;

19. Hospital Dr. Peset, Valencia, Spain;

20. Queen Elizabeth II Health Sciences Centre, Halifax, Canada;

21. Kantonsspital Winterthur, Winterthur, Switzerland;

22. Peking University People’s Hospital, Beijing, China;

23. Dana-Farber Cancer Institute, Boston, MA;

24. Department of Hematology, University of Nantes, Nantes, France;

25. Institut Universitaire du Cancer, Toulouse-Oncopole, France;

26. Centre Hospitalier Régional Universitaire de Nancy, Université de Lorraine, Nancy, France;

27. Hopital Saint Louis, Paris, France;

28. Blood Disease Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, China;

29. Centre Hospitalier Universitaire Purpan/Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France;

30. Hôpital Saint-Antoine, Paris, France;

31. Unite de Genomique du Myelome, Centre Hospitalier Universitaire Rangueil, Toulouse, France;

32. Hôpital de la Milétrie, Centre Hospitalier Universitaire INSERM, Poitiers, France;

33. Celgene Corporation, Summit, NJ;

34. Centre Hospitalier Universitaire Hôpital Bretonneau, Tours Cedex, France; and

35. Bordeaux Hospital University Center (Centre Hospitalier Universitaire), Bordeaux, France

Abstract

Key Points Rd continuous significantly extended OS compared with MPT and resulted in comparable OS to that with Rd18 in patients with multiple myeloma. Patients achieving complete or very good partial response with Rd benefited greatly from continuous vs fixed treatment in terms of PFS.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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