Antenatal management in fetal and neonatal alloimmune thrombocytopenia: a systematic review

Author:

Winkelhorst Dian1,Murphy Michael F.23,Greinacher Andreas4,Shehata Nadine56,Bakchoul Taman47,Massey Edwin8,Baker Jillian9,Lieberman Lani10,Tanael Susano11,Hume Heather12,Arnold Donald M.13,Baidya Shoma14,Bertrand Gerald15,Bussel James16,Kjaer Mette1718,Kaplan Cécile19,Kjeldsen-Kragh Jens20,Oepkes Dick1,Ryan Greg21

Affiliation:

1. Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands;

2. Blood Transfusion Medicine, Oxford University Hospitals, and

3. NHS Blood and Transplant, University of Oxford, Oxford, United Kingdom;

4. Institute of Immunology and Transfusion Medicine, University Hospital Greifswald, Greifswald, Germany;

5. Department of Medicine, and

6. Department of Obstetric Medicine, Mount Sinai Hospital, Toronto, ON, Canada;

7. Center for Clinical Transfusion Medicine, University of Tuebingen, Tuebingen, Germany;

8. Diagnostic and Therapeutic Services, NHS Blood and Transplant, Oxford, United Kingdom;

9. Hospital for Sick Children, St. Michael’s Hospital, Toronto, ON, Canada;

10. University Health Network, University of Toronto, Toronto, ON, Canada;

11. Center for Innovation, Canadian Blood Services, Toronto, ON, Canada;

12. Division of Hematology-Oncology, Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, QC, Canada;

13. Division of Hematology and Thromboembolism, McMaster University, Hamilton, ON, Canada;

14. Australian Red Cross Blood Service, Brisbane, QLD, Australia;

15. Platelet Immunology Department, French Blood Services of Brittany, Rennes, France;

16. Weill Cornell Medical College, Cornell University, New York, NY;

17. Department of Laboratory Medicine, Diagnostic Clinic, University Hospital of North Norway, Tromsø, Norway;

18. Finnmark Hospital Trust, Hammerfest, Norway;

19. Institut National de la Transfusion Sanguine, Paris, France;

20. Department of Clinical Immunology and Transfusion Medicine, Regional and University Laboratories, Region Skåne, Lund, Sweden; and

21. Fetal Medicine Unit, Mount Sinai Hospital, Toronto, ON, Canada

Abstract

Key Points The systematic review suggests that first-line antenatal management in FNAIT is weekly IVIG administration. Noninvasive management is effective without the relatively high rate of adverse outcomes seen in invasive strategies.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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