RARα2 expression confers myeloma stem cell features

Author:

Yang Ye1,Shi Jumei2,Tolomelli Giulia3,Xu Hongwei1,Xia Jiliang1,Wang He1,Zhou Wen1,Zhou Yi1,Das Satyabrata1,Gu Zhimin1,Levasseur Dana1,Zhan Fenghuang1,Tricot Guido1

Affiliation:

1. Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA;

2. Department of Hematology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China; and

3. Department of Hematology and Oncology “L. e A. Seràgnoli,” St Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy

Abstract

Key Points RARα2 activates Wnt and hedgehog pathways in maintaining myeloma stem cell features and drug resistance.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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