Preinfusion polyfunctional anti-CD19 chimeric antigen receptor T cells are associated with clinical outcomes in NHL

Author:

Rossi John1,Paczkowski Patrick2,Shen Yueh-Wei1,Morse Kevin2,Flynn Brianna2,Kaiser Alaina2,Ng Colin2,Gallatin Kyle2,Cain Tom2,Fan Rong3,Mackay Sean2,Heath James R.4,Rosenberg Steven A.5,Kochenderfer James N.6,Zhou Jing2,Bot Adrian1

Affiliation:

1. Kite, a Gilead Company, Santa Monica, CA;

2. IsoPlexis, Branford, CT;

3. Department of Biomedical Engineering, Yale School of Engineering and Applied Science, Yale University, New Haven, CT;

4. Divison of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA; and

5. Surgery Branch, and

6. Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD

Abstract

Key Points The PSI of manufactured CAR T cells was associated with clinical response and toxicities. Monitoring CAR T-cell polyfunctionality as a key product attribute may complement other characteristics including T-cell proliferation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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