High NPM1-mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML-Reference-Cited by-同舟云学术

High NPM1-mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML

Published:2018-06-21 Issue:25 Volume:131 Page:2816-2825
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Patel Sanjay S.¹,Kuo Frank C.¹,Gibson Christopher J.²,Steensma David P.²,Soiffer Robert J.²,Alyea Edwin P.²,Chen Yi-Bin A.³,Fathi Amir T.³,Graubert Timothy A.³,Brunner Andrew M.³,Wadleigh Martha²,Stone Richard M.²,DeAngelo Daniel J.²,Nardi Valentina⁴,Hasserjian Robert P.⁴,Weinberg Olga K.¹⁵

Affiliation:

1. Department of Pathology, Brigham and Women’s Hospital, Boston, MA;

2. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA;

3. Massachusetts General Hospital Cancer Center, Boston, MA;

4. Department of Pathology, Massachusetts General Hospital, Boston, MA; and

5. Department of Pathology, Boston Children’s Hospital, Boston, MA

Abstract

Key Points High NPM1-mutant allele burden at diagnosis is associated with poor clinical outcome in de novo AML. The adverse effect of high NPM1-mutant allele burden is independent of comutations and clinical variables.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/25/2816/1466266/blood828467.pdf

Reference32 articles.

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3. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia;Ley;N Engl J Med,2013

4. Prognostic significance of NPM1 mutations in the absence of FLT3-internal tandem duplication in older patients with acute myeloid leukemia: a SWOG and UK National Cancer Research Institute/Medical Research Council report;Ostronoff;J Clin Oncol,2015

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