North American ATLL has a distinct mutational and transcriptional profile and responds to epigenetic therapies-Reference-Cited by-同舟云学术

North American ATLL has a distinct mutational and transcriptional profile and responds to epigenetic therapies

Published:2018-10-04 Issue:14 Volume:132 Page:1507-1518
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Shah Urvi A.¹²³^ORCID,Chung Elaine Y.²,Giricz Orsi³,Pradhan Kith³,Kataoka Keisuke⁴,Gordon-Mitchell Shanisha³,Bhagat Tushar D.³^ORCID,Mai Yun²,Wei Yongqiang²⁵,Ishida Elise²,Choudhary Gaurav S.³,Joseph Ancy⁶^ORCID,Rice Ronald⁷,Gitego Nadege³,Parrish Crystall³,Bartenstein Matthias³^ORCID,Goel Swati¹,Mantzaris Ioannis¹,Shastri Aditi¹³,Derman Olga¹,Binder Adam¹,Gritsman Kira¹²,Kornblum Noah¹,Braunschweig Ira¹,Bhagat Chirag⁸,Hall Jeff⁸,Graber Armin⁸,Ratner Lee⁶,Wang Yanhua⁹,Ogawa Seishi⁴,Verma Amit¹³,Ye B. Hilda²^ORCID,Janakiram Murali¹^ORCID

Affiliation:

1. Department of Oncology, Montefiore Medical Center, Bronx, NY;

2. Department of Cell Biology and

3. Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY;

4. Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan;

5. Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China;

6. Division of Oncology, Washington University School of Medicine, St Louis, MO;

7. Department of Pathology, Phelps Hospital, Northwell Health, Sleepy Hollow, NY;

8. Genoptix, Carlsbad, CA; and

9. Department of Pathology, Montefiore Medical Center, Bronx, NY

Abstract

Key Points North American ATLL has a distinct genomic landscape with a high frequency of prognostic epigenetic mutations, including EP300 mutations. ATLL samples with mutated EP300 have compromised p53 function and are selectively sensitive to decitabine treatment.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/132/14/1507/1407054/blood824607.pdf

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