Distinct signaling programs control human hematopoietic stem cell survival and proliferation

Author:

Knapp David J. H. F.1ORCID,Hammond Colin A.1,Aghaeepour Nima2,Miller Paul H.1,Pellacani Davide1,Beer Philip A.1,Sachs Karen2,Qiao Wenlian3,Wang WeiJia3,Humphries R. Keith1,Sauvageau Guy4,Zandstra Peter W.3,Bendall Sean C.5,Nolan Garry P.2,Hansen Carl6,Eaves Connie J.1

Affiliation:

1. Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada;

2. Baxter Laboratory for Stem Cell Biology, Department of Microbiology & Immunology, Stanford University, Palo Alto, CA;

3. Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada;

4. Molecular Genetics of Stem Cells Laboratory, Institute of Research in Immunology and Cancer, University of Montreal, Montreal, QC, Canada;

5. Department of Pathology, Stanford University, Palo Alto, CA; and

6. Centre for High-Throughput Biology, University of British Columbia, Vancouver, BC, Canada

Abstract

Key Points Human HSCs show higher tonic signaling activity in multiple pathways than MPPs. Growth factor–activated AKT and β-catenin in human HSCs regulate their survival and mitogenesis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3