Natural history of autoimmune lymphoproliferative syndrome associated with FAS gene mutations

Author:

Price Susan1,Shaw Pamela A.2,Seitz Amy3,Joshi Gyan4,Davis Joie1,Niemela Julie E.5,Perkins Katie6,Hornung Ronald L.6,Folio Les7,Rosenberg Philip S.8,Puck Jennifer M.9,Hsu Amy P.3,Lo Bernice1,Pittaluga Stefania10,Jaffe Elaine S.10,Fleisher Thomas A.5,Rao V. Koneti1,Lenardo Michael J.1

Affiliation:

1. Molecular Development Section, Laboratory of Immunology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD;

2. Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;

3. Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD;

4. Biostatistics Research Branch, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD;

5. Immunology Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD;

6. Clinical Services Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD;

7. Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD;

8. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD;

9. Department of Pediatrics and Institute for Human Genetics, University of California at San Francisco, San Francisco, CA; and

10. Hematopathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD

Abstract

Key Points Less than 60% of individuals who inherit a FAS mutation have a clinical manifestation of ALPS, implying a high carrier rate. Major causes of morbidity and mortality in ALPS patients are sepsis following splenectomy and development of lymphoma.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Cited by 195 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3