Control of coronavirus infection through plasmacytoid dendritic-cell–derived type I interferon-Reference-Cited by-全球学者库

Control of coronavirus infection through plasmacytoid dendritic-cell–derived type I interferon

Published:2006-09-19 Issue:3 Volume:109 Page:1131-1137
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Cervantes-Barragan Luisa¹²,Züst Roland¹,Weber Friedemann³,Spiegel Martin³,Lang Karl S.⁴,Akira Shizuo⁵,Thiel Volker¹,Ludewig Burkhard¹

Affiliation:

1. Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland;

2. Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades, Mexico City, Mexico;

3. Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Freiburg, Germany;

4. Institute of Experimental Immunology, University Hospital, Zurich, Switzerland;

5. Department of Host Defense, Osaka University, Osaka, Japan

Abstract

Abstract This study demonstrates a unique and crucial role of plasmacytoid dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) in the pathogenesis of mouse coronavirus infection. pDCs controlled the fast replicating mouse hepatitis virus (MHV) through the immediate production of type I IFNs. Recognition of MHV by pDCs was mediated via TLR7 ensuring a swift IFN-α production following encounter with this cytopathic RNA virus. Furthermore, the particular type I IFN response pattern was not restricted to the murine coronavirus, but was also found in infection with the highly cytopathic human severe acute respiratory syndrome (SARS) coronavirus. Taken together, our results suggest that rapid production of type I IFNs by pDCs is essential for the control of potentially lethal coronavirus infections.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/109/3/1131/1287250/zh800307001131.pdf

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