A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production-Reference-Cited by-同舟云学术

A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production

Published:2017-02-23 Issue:8 Volume:129 Page:959-969
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Yu Hua¹^ORCID,Borsotti Chiara²,Schickel Jean-Nicolas¹,Zhu Shu¹,Strowig Till¹,Eynon Elizabeth E.¹,Frleta Davor³,Gurer Cagan³,Murphy Andrew J.³,Yancopoulos George D.³,Meffre Eric¹,Manz Markus G.²,Flavell Richard A.¹⁴^ORCID

Affiliation:

1. Department of Immunobiology, Yale University, New Haven, CT;

2. Division of Hematology, University Hospital Zurich, Zurich, Switzerland;

3. Regeneron Pharmaceuticals, Inc., Tarrytown, NY; and

4. Howard Hughes Medical Institute, Yale University, New Haven, CT

Abstract

Key Points Human IL-6 improves T-cell engraftment and serum IgG production in humanized mice. IgG-switched memory B cells in IL-6 knock-in mice displayed a diverse antibody repertoire and high specificity against immunized antigen.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/8/959/1465809/blood709584.pdf

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