Wogonoside induces cell cycle arrest and differentiation by affecting expression and subcellular localization of PLSCR1 in AML cells

Author:

Chen Yan1,Hui Hui1,Yang Hao1,Zhao Kai1,Qin Yansu1,Gu Cong2,Wang Xiaotang1,Lu Na1,Guo Qinglong1

Affiliation:

1. State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing, People’s Republic of China; and

2. Animal Medicine College, Veterinary Medicine College, Yangzhou University, Yangzhou, People’s Republic of China

Abstract

Key Points Wogonoside induces cell cycle arrest and differentiation. Wogonoside acts by changing PLSCR1 expression and subcellular localization in the nucleus and by PLSCR1-related molecular events.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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