Anti-CD45 radioimmunotherapy using 211At with bone marrow transplantation prolongs survival in a disseminated murine leukemia model-Reference-Cited by-同舟云学术

Anti-CD45 radioimmunotherapy using 211At with bone marrow transplantation prolongs survival in a disseminated murine leukemia model

Published:2013-05-02 Issue:18 Volume:121 Page:3759-3767
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Orozco Johnnie J.¹²,Bäck Tom³,Kenoyer Aimee¹,Balkin Ethan R.⁴,Hamlin Donald K.⁴,Wilbur D. Scott⁴,Fisher Darrell R.⁵,Frayo Shani L.¹,Hylarides Mark D.¹,Green Damian J.¹⁶,Gopal Ajay K.¹⁶,Press Oliver W.¹⁶,Pagel John M.¹⁶

Affiliation:

1. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

2. Hematology Division, Department of Medicine, University of Washington, Seattle, WA;

3. Department of Radiation Physics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;

4. Radiation Oncology, University of Washington, Seattle, WA;

5. Pacific Northwest National Laboratory, Richland, WA; and

6. Medical Oncology, Department of Medicine, University of Washington, Seattle, WA

Abstract

Key Points Astatination of anti-CD45 antibody via a closo-decaborate compound yields a stable conjugate that targets radiation to hematologic organs. 211At-anti-CD45 radioimmunotherapy combined with bone marrow transplantation prolongs survival in a disseminated murine leukemia model.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/18/3759/1363680/3759.pdf

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