Erythroferrone inhibits the induction of hepcidin by BMP6

Author:

Arezes João1,Foy Niall2,McHugh Kirsty3,Sawant Anagha4,Quinkert Doris3,Terraube Virginie2,Brinth Alette2,Tam May56,LaVallie Edward R.5,Taylor Stephen7,Armitage Andrew E.1,Pasricha Sant-Rayn189ORCID,Cunningham Orla2,Lambert Matthew2,Draper Simon J.3ORCID,Jasuja Reema4,Drakesmith Hal110

Affiliation:

1. Medical Research Council (MRC) Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom;

2. BioMedicine Design, Pfizer Biotherapeutics Research and Development (R&D), Dublin, Ireland;

3. The Jenner Institute, University of Oxford, Oxford, United Kingdom;

4. Rare Disease Research Unit, Pfizer Inc., Cambridge, MA;

5. BioMedicine Design, Pfizer Biotherapeutics R&D, Cambridge, MA;

6. Pharmacokinetics, Dynamics and Metabolism, Pfizer Biotherapeutics R&D, Andover, MA;

7. Computational Biology Research Group, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom;

8. Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia;

9. Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia; and

10. Haematology Theme Oxford Biomedical Research Centre, Oxford, United Kingdom

Abstract

Key Points ERFE suppresses BMP/SMAD signaling in vitro and in vivo. ERFE inhibits hepcidin induction by BMP5, BMP6, and BMP7.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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