CD33 target validation and sustained depletion of AML blasts in long-term cultures by the bispecific T-cell–engaging antibody AMG 330

Author:

Krupka Christina123,Kufer Peter4,Kischel Roman4,Zugmaier Gerhard4,Bögeholz Jan12,Köhnke Thomas12,Lichtenegger Felix S.125,Schneider Stephanie1,Metzeler Klaus H.1,Fiegl Michael1,Spiekermann Karsten1678,Baeuerle Patrick A.4,Hiddemann Wolfgang16,Riethmüller Gert3,Subklewe Marion1278

Affiliation:

1. Department of Internal Medicine III, Klinikum der Universität München, Munich, Germany;

2. Clinical Cooperation Group Immunotherapy at the Helmholtz Institute Munich, Munich, Germany;

3. Institute for Immunology, Ludwig-Maximilians-University, Munich, Germany;

4. AMGEN Research (Munich) GmbH, Munich, Germany;

5. Division of Clinical Pharmacology, Department of Internal Medicine IV, Klinikum der Universität München, Munich, Germany;

6. Clinical Cooperation Group Leukemia at the Helmholtz Institute Munich, Munich, Germany;

7. German Cancer Consortium (DKTK), Heidelberg, Germany; and

8. German Cancer Research Center (DKFZ), Heidelberg, Germany

Abstract

Key Points CD33 expression levels in AML correlate with specific disease characteristics. Potent cytotoxicity against primary AML blasts is mediated by a CD33/CD3-bispecific antibody.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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