Monoclonal B-cell lymphocytosis in healthy blood donors: an unexpectedly common finding

Author:

Shim Youn K.1,Rachel Jane M.2,Ghia Paolo34,Boren Jeff2,Abbasi Fatima5,Dagklis Antonis34,Venable Geri6,Kang Jiyeon7,Degheidy Heba5,Plapp Fred V.2,Vogt Robert F.8,Menitove Jay E.6,Marti Gerald E.9

Affiliation:

1. Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry, Atlanta, GA;

2. Department of Pathology, St. Luke's Hospital, Kansas City, MO;

3. Division of Molecular Oncology and

4. Department of Onco-Hematology, Università Vita-Salute San Raffaele and Istituto Scientifico San Raffaele, Milano, Italy;

5. Division of Cellular and Gene Therapies, Office of Cellular, Tissue and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD;

6. Community Blood Center, Kansas City, MO;

7. MeSun Health Services, Lawrenceville, GA;

8. Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA; and

9. Division of Immunology and Hematology Devices, Office of In Vitro Diagnostic Device Evaluation and Safety, US Food and Drug Administration, Silver Spring, MD

Abstract

Key Points The prevalence of MBL among blood donors is much higher than previously reported. Although uncommon, higher-risk MBL phenotypes and genotypes were observed.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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