Plant-based oral tolerance to hemophilia therapy employs a complex immune regulatory response including LAP+CD4+ T cells-Reference-Cited by-同舟云学术

Plant-based oral tolerance to hemophilia therapy employs a complex immune regulatory response including LAP+CD4+ T cells

Published:2015-04-09 Issue:15 Volume:125 Page:2418-2427
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Wang Xiaomei¹,Su Jin²,Sherman Alexandra¹,Rogers Geoffrey L.¹,Liao Gongxian³,Hoffman Brad E.¹,Leong Kam W.⁴,Terhorst Cox³,Daniell Henry²,Herzog Roland W.¹

Affiliation:

1. Department of Pediatrics, College of Medicine, University of Florida, Gainesville, FL;

2. Departments of Biochemistry and Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA;

3. Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA; and

4. Department of Biomedical Engineering, Columbia University, New York, NY

Abstract

Key Points Coadministering FIX orally and systemically induces tolerance via complex immune regulation, involving tolerogenic dendritic and T-cell subsets. Induced CD4+CD25−LAP+ regulatory T cells with increased IL-10 and TGF-β expression and CD4+CD25+ regulatory T cells suppress antibody formation against FIX.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/15/2418/1384093/2418.pdf

Reference50 articles.

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4. Oral tolerance.;Weiner;Immunol Rev,2011

5. Mechanism of oral tolerance induction to therapeutic proteins.;Wang;Adv Drug Deliv Rev,2013

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