Early molecular response and female sex strongly predict stable undetectable BCR-ABL1, the criteria for imatinib discontinuation in patients with CML

Author:

Branford Susan123,Yeung David T.124,Ross David M.245,Prime Jodi A.1,Field Chani R.1,Altamura Haley K.1,Yeoman Alexandra L.1,Georgievski Jasmina1,Jamison Bronte A.1,Phillis Stuart1,Sullivan Brad1,Briggs Nancy E.6,Hertzberg Mark78,Seymour John F.79,Reynolds John10,Hughes Timothy P.247

Affiliation:

1. Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia;

2. School of Medicine,

3. School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia;

4. Department of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia;

5. Department of Haematology and Genetic Pathology, Flinders University and Medical Centre, Adelaide, Australia;

6. Discipline of Public Health, University of Adelaide, Adelaide, Australia;

7. Australasian Leukaemia and Lymphoma Group, East Melbourne, Australia;

8. Westmead Hospital, Westmead and The University of Sydney, Sydney, Australia;

9. Peter MacCallum Cancer Centre, East Melbourne, and University of Melbourne, Australia; and

10. Faculty of Health, Deakin University, Melbourne, Australia

Abstract

Key PointsIndependent predictors of stable, undetectable BCR-ABL1 during first-line imatinib therapy were female sex and the BCR-ABL1 value at 3 months. Time to achieve an MMR influenced time to stable, undetectable BCR-ABL1, suggesting slower dynamics of BCR-ABL1 decline with delayed MMR.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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