Significance of FAB subclassification of “acute myeloid leukemia, NOS” in the 2008 WHO classification: analysis of 5848 newly diagnosed patients

Author:

Walter Roland B.123,Othus Megan4,Burnett Alan K.5,Löwenberg Bob6,Kantarjian Hagop M.7,Ossenkoppele Gert J.8,Hills Robert K.5,van Montfort Kees G. M.9,Ravandi Farhad7,Evans Anna5,Pierce Sherry R.7,Appelbaum Frederick R.110,Estey Elihu H.12

Affiliation:

1. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

2. Division of Hematology, Department of Medicine, and

3. Department of Epidemiology, University of Washington, Seattle, WA;

4. Southwest Oncology Group Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA;

5. Department of Haematology, School of Medicine, Cardiff University, Cardiff, United Kingdom;

6. Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands;

7. Leukemia Department, The University of Texas MD Anderson Cancer Center, Houston, TX;

8. Division of Hematology, VU University Medical Center, Amsterdam, The Netherlands;

9. Department of Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands; and

10. Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA

Abstract

Key Points The FAB type (ie, M0-M7) does not provide prognostic information for cases of “AML, NOS” in the 2008 WHO classification.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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