A randomized phase 3 trial of thalidomide and prednisone as maintenance therapy after ASCT in patients with MM with a quality-of-life assessment: the National Cancer Institute of Canada Clinicals Trials Group Myeloma 10 Trial

Author:

Stewart A. Keith1,Trudel Suzanne2,Bahlis Nizar J.3,White Darrell4,Sabry Waleed5,Belch Andrew6,Reiman Tony7,Roy Jean8,Shustik Chaim9,Kovacs Michael J.10,Rubinger Morel11,Cantin Guy12,Song Kevin13,Tompkins Kirsty A.14,Marcellus Deb C.15,Lacy Martha Q.16,Sussman Jonathan15,Reece Donna2,Brundage Michael17,Harnett Erica L.18,Shepherd Lois18,Chapman Judy-Anne W.18,Meyer Ralph M.18

Affiliation:

1. Mayo Clinic, Scottsdale, AZ;

2. Princess Margaret Hospital, Toronto, ON;

3. Tom Baker Cancer Centre, Calgary, AB;

4. QEII Health Sciences Center, Halifax, NS;

5. Saskatoon Cancer Centre, Saskatoon, SK;

6. Cross Cancer Institute, Edmonton, AB;

7. Saint John Regional Cancer Centre, St John, NB;

8. Maisonneuve-Rosemont Hospital, Montreal, QC;

9. McGill University, Montreal, QC;

10. London Health Sciences Centre, London, ON;

11. Cancer Care Manitoba, Winnipeg, MB;

12. Centre Hospitalier Affilié Hopital Enfant-Jesus, Quebec City, QC;

13. British Columbia Cancer Agency Vancouver, Vancouver, BC;

14. Dr H. Bliss Murphy Cancer Centre, St John's, NL;

15. Juravinski Cancer Centre, Hamilton, ON;

16. Mayo Clinic, Rochester, MN;

17. Cancer Centre of Southeastern Ontario, Kingston ON; and

18. National Cancer Institute of Canada Clinical Trials Group, Kingston, ON

Abstract

Key Points Thalidomide and prednisone maintenance after transplantation improves progression-free but not overall survival.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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