The early activation of memory B cells from Wiskott-Aldrich syndrome patients is suppressed by CD19 downregulation-Reference-Cited by-全球学者库

The early activation of memory B cells from Wiskott-Aldrich syndrome patients is suppressed by CD19 downregulation

Published:2016-06-21 Issue:13 Volume:128 Page:1723-1734
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Bai Xiaoming¹,Zhang Yongjie¹,Huang Lu¹,Wang Jinzhi¹,Li Wenyan¹,Niu Linlin¹,Jiang Hongyan¹,Dai Rongxin¹,Zhou Lina¹,Zhang Zhiyong¹,Miller Heather²,Song Wenxia³,Zhao Xiaodong¹,Liu Chaohong⁴

Affiliation:

1. Chongqing Key Laboratory of Child Infection and Immunity, Children’s Hospital of Chongqing Medical University, Chongqing, China;

2. Department of Intracellular Pathogens, National Institute of Allergy and Infectious Diseases, Hamilton, MT;

3. Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD; and

4. Department of Pathogen Biology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, China

Abstract

Key Points BCR clustering and B-cell spreading were decreased in WAS memory B cells. CD19-Btk–mediated signaling was decreased, and FcγRIIB-SHIP–mediated signaling was increased in WAS memory B cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/13/1723/1504739/1723.pdf

Reference48 articles.

1. B cell antigen receptor signaling: roles in cell development and disease.;Gauld;Science,2002

2. The complexity of signaling pathways activated by the BCR.;DeFranco;Curr Opin Immunol,1997

3. Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling.;Kurosaki;J Exp Med,1995

4. Follicular dendritic cell-derived antigen and accessory activity in initiation of memory IgG responses in vitro.;Wu;J Immunol,1996

5. Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response.;Wykes;J Immunol,1998

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