Hereditary risk factors for thrombophilia and probability of venous thromboembolism during pregnancy and the puerperium

Author:

Gerhardt Andrea12,Scharf Rüdiger E.2,Greer Ian A.3,Zotz Rainer B.24

Affiliation:

1. Blutgerinnung Ulm, Ulm, Germany;

2. Department of Haemostasis, Haemotherapy and Transfusion Medicine, Heinrich Heine University Medical Centre, Düsseldorf, Germany;

3. Faculty of Biology Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom; and

4. Institute for Laboratory Medicine, Blood Coagulation and Transfusion Medicine, Düsseldorf, Germany

Abstract

Key Points Women with severe thrombophilia have a high absolute risk of pregnancy-associated VTE independent of a positive family history of VTE. These women should be considered for routine antenatal thromboprophylaxis regardless of family history of VTE.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference46 articles.

1. Pregnancy-related mortality surveillance--United States, 1991--1999.;Chang;MMWR Surveill Summ,2003

2. Prevalence of the post-thrombotic syndrome in young women with previous venous thromboembolism.;McColl;Br J Haematol,2000

3. A 16-year haemodynamic follow-up of women with pregnancy-related medically treated iliofemoral deep venous thrombosis.;Rosfors;Eur J Vasc Endovasc Surg,2001

4. Saving Mothers’ Lives: Reviewing maternal deaths to make motherhood safer: 2006-2008. The Eighth Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom.;Cantwell;BJOG,2011

5. Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study.;Heit;Ann Intern Med,2005

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