Umbilical cord blood–derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect-Reference-Cited by-同舟云学术

Umbilical cord blood–derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect

Published:2016-02-25 Issue:8 Volume:127 Page:1044-1051
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Brunstein Claudio G.¹²,Miller Jeffrey S.¹²,McKenna David H.³⁴,Hippen Keli L.¹⁵,DeFor Todd E.¹⁶,Sumstad Darin¹⁴,Curtsinger Julie¹⁵,Verneris Michael R.¹⁵,MacMillan Margaret L.¹⁵,Levine Bruce L.⁷,Riley James L.⁷,June Carl H.⁷,Le Chap⁶⁸,Weisdorf Daniel J.¹²,McGlave Philip B.¹²,Blazar Bruce R.¹⁵,Wagner John E.¹⁵

Affiliation:

1. University of Minnesota Blood and Marrow Transplant Program,

2. Division of Hematology, Oncology and Transplantation,

3. Department of Laboratory Medicine and Pathology,

4. Molecular and Cellular Therapeutics Facility,

5. Division of Pediatric Blood and Marrow Transplantation, and

6. Masonic Cancer Center, University of Minnesota, Minneapolis, MN;

7. Department of Pathology and Laboratory Medicine and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; and

8. Division of Biostatistics, University of Minnesota, Minneapolis, MN

Abstract

Key Points KT64/86 artificial antigen–presenting cells culture stimulation provides marked expansion of Tregs. In the context of sirolimus, mycophenolate mofetil immunosuppression, adoptive transfer of Tregs resulted in low risk of acute GVHD.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/8/1044/1394557/1044.pdf

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