PBX3 is an important cofactor of HOXA9 in leukemogenesis-Reference-Cited by-同舟云学术

PBX3 is an important cofactor of HOXA9 in leukemogenesis

Published:2013-02-21 Issue:8 Volume:121 Page:1422-1431
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Li Zejuan¹,Zhang Zhiyu²,Li Yuanyuan¹,Arnovitz Stephen¹,Chen Ping¹,Huang Hao¹,Jiang Xi¹,Hong Gia-Ming¹,Kunjamma Rejani B.¹,Ren Haomin¹,He Chunjiang¹,Wang Chong-Zhi²,Elkahloun Abdel G.³,Valk Peter J. M.⁴,Döhner Konstanze⁵,Neilly Mary Beth¹,Bullinger Lars⁵,Delwel Ruud⁴,Löwenberg Bob⁴,Liu Paul P.³,Morgan Richard⁶,Rowley Janet D.¹,Yuan Chun-Su²,Chen Jianjun¹

Affiliation:

1. Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL;

2. Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL;

3. Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD;

4. Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands;

5. Department of Internal Medicine III, University of Ulm, Ulm, Germany; and

6. Postgraduate Medical School, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom

Abstract

Key Points PBX3 is a critical co-factor of HOXA9 in AMLs, particularly those carrying MLL rearrangements. Targeting HOXA9/PBX3 interaction holds a therapeutic potential to treat leukemia.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/8/1422/1369251/zh800813001422.pdf

Reference48 articles.

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4. Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny.;Pineault;Exp Hematol,2002

5. HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells.;Shen;Mol Cell Biol,1999

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