Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling-Reference-Cited by-同舟云学术

Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling

Published:2013-02-07 Issue:6 Volume:121 Page:930-939
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Fulzele Keertik¹,Krause Daniela S.²,Panaroni Cristina¹,Saini Vaibhav¹,Barry Kevin J.¹,Liu Xiaolong¹,Lotinun Sutada³,Baron Roland¹³,Bonewald Lynda⁴,Feng Jian Q.⁵,Chen Min⁶,Weinstein Lee S.⁶,Wu Joy Y.¹,Kronenberg Henry M.¹,Scadden David T.²,Divieti Pajevic Paola¹

Affiliation:

1. Endocrine Unit and

2. Center of Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA;

3. Harvard School of Dental Medicine, Boston, MA;

4. Department of Oral Biology, University of Missouri at Kansas City, Kansas City, MO;

5. Department of Biomedical Sciences, Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, TX; and

6. Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD

Abstract

Key Points Deletion of Gsα in osteocytes induces severe osteopenia and a dramatic expansion of cells of the myeloid lineage. Osteocytes regulate hematopoiesis and specifically contribute to myelopoiesis by secreting proliferative factors such as G-CSF.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/6/930/1367674/zh800613000930.pdf

Reference33 articles.

1. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages.;Akashi;Nature,2000

2. Diverse mechanisms regulate stem cell self-renewal.;Molofsky;Curr Opin Cell Biol,2004

3. Uncertainty in the niches that maintain haematopoietic stem cells.;Kiel;Nat Rev Immunol,2008

4. Osteoblastic cells regulate the haematopoietic stem cell niche.;Calvi;Nature,2003

5. Identification of the haematopoietic stem cell niche and control of the niche size.;Zhang;Nature,2003

Cited by 140 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Bone Marrow–Resident Stem Cells;Resident Stem Cells and Regenerative Therapy;2024

2. GNAS locus: bone related diseases and mouse models;Frontiers in Endocrinology;2023-10-18

3. The Multifaceted Effects of Osteocytic TGFβ Signaling on the Skeletal and Extraskeletal Functions of Bone;Current Osteoporosis Reports;2023-07-03

4. The hematopoietic microenvironment: a network of niches for the development of all blood cell lineages;Journal of Leukocyte Biology;2023-06-30

5. Targeting osteocytes vs osteoblasts;Bone;2023-05