High-dimensional immunomonitoring models of HIV-1–specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control

Author:

Ndhlovu Zaza M.12,Chibnik Lori B.3,Proudfoot Jacqueline1,Vine Seanna1,McMullen Ashley1,Cesa Kevin1,Porichis Filippos1,Jones R. Brad1,Alvino Donna Marie1,Hart Meghan G.1,Stampouloglou Eleni1,Piechocka-Trocha Alicja1,Kadie Carl4,Pereyra Florencia1,Heckerman David5,De Jager Philip L.26,Walker Bruce D.178,Kaufmann Daniel E.189

Affiliation:

1. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard, Massachusetts General Hospital, Harvard Medical School, Boston, MA;

2. HIV Pathogenesis Programme, Doris Duke Medical Research Institute and KwaZulu-Natal Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa;

3. Program in Translational Neuropsychiatric Genomics, Institute for The Neurosciences, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA;

4. Microsoft Research, Redmond, WA;

5. Microsoft Research, Los Angeles, CA;

6. The Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA;

7. Howard Hughes Medical Institute, Chevy Chase, MD;

8. Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA; and

9. Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, QC

Abstract

Key Points Immune monitoring models integrating multiple functions of HIV-1–specific CD8 T cells distinguish controllers from subjects with progressive HIV-1 infection. This strategy may have important applications in predictive model development and immune monitoring of HIV-1 vaccine trials.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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