Effects on Survival of Non-Myeloablative Chemoimmunotherapy Compared to High-Dose Chemotherapy Followed By Autologous Stem Cell Transplantation (HDC-ASCT) As Consolidation Therapy in Patients with Primary CNS Lymphoma - Results of an International Randomized Phase III Trial (MATRix/IELSG43)

Author:

Illerhaus Gerald1,Ferreri Andrés J.M.2,Binder Mascha3,Borchmann Peter4,Hasenkamp Justin5,Stilgenbauer Stephan6,Roeth Alexander7,Weber Thomas8,Egerer Gerlinde9,Ernst Thomas10,Hertenstein Bernd11,Lenz Georg12,Kobbe Guido13,Brunnberg Uta14,Schmidt Christian15,Kneba Michael16,Dreyling Martin17,Möhle Robert18,Panse Jens19,Heinicke Thomas20,Schroll Sebastian21,Larsen Thomas S.22,Salwender Hans23,Naumann Ralph24,Hess Georg25,Thurner Lorenz26,Pukrop Tobias27,Keller Ulrich28,Blystadt Anne Kirsti29,Kroschinsky Frank P.30,Re Francesca31,Pulczynski Elisa32,Orsucci Lorella33,Pospiech Lisa34,Deckert Martina35,Ponzoni Maurilio36,Wendler Julia34,Valk Elke1,Calimeri Teresa37,Kasenda Benjamin38,Trepel Martin39,Fricker Heidi40,von Gottberg Philipp41,Burger Elvira42,Ihorst Gabriele43,Grishina Olga44,Hader Claudia45,Zucca Emanuele46,Finke Jürgen42,Schorb Elisabeth42

Affiliation:

1. 1Department of Hematology, Oncology Stem Cell Transplantation and Palliative Care, Klinikum Stuttgart, Stuttgart, Germany

2. 2Lymphoma Unit, Department of Onco-Hematology, IRCCS San Raffaele Scientific Institute, Milan, Italy

3. 3Martin-luther-University Halle-Wittenberg, Halle (saale), DEU

4. 4Cologne Lymphoma Working Group, Department of Internal Medicine I, University Hospital of Cologne, Koeln, Germany

5. 5University Medicine Göttingen, Göttingen, DEU

6. 6Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany

7. 7Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, Essen, Germany

8. 8Department of Internal Medicine IV, Haematology and Oncology, University Hospital Halle (Saale), Martin-Luther-University Halle-Wittenberg, Halle, Germany

9. 9Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany

10. 10Hematology/Oncology, Jena University Hospital, Jena, Germany

11. 11Klinikum Bremen Mitte, Bremen, Germany

12. 12Department of Medicine A, Department of Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany

13. 13Department of Hematology, Oncology and Clinical Immunology, University Hospital Düsseldorf, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany

14. 14Department of Medicine 2, Hematology and Oncology, University Hospital Frankfurt, Frankfurt, Germany

15. 15Department of Medicine III, University Hospital, LMU Munich, Munich, Germany

16. 16Univ. Schleswig-Holstein, Campus Kiel, Kiel, Germany

17. 17Department of Medicine III, Klinikum Der Universitaet Muenchen-Campus Grosshadern, Munich, Germany

18. 18Department of Hematology and Oncology, University of Tübingen, Tübingen, Germany

19. 19Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany

20. 20Department of Hematology and Oncology, University Hospital Magdeburg, Magdeburg, Germany

21. 21Dept. of Hematology and Oncology, Städtisches Klinikum Braunschweig gGmbH, Braunschweig, Germany

22. 22Department of Hematology, Odense University Hospital, Odense, Denmark

23. 23Asklepios Tumorzentrum Hamburg, AK Altona and AK St. Georg, Hamburg, Germany

24. 24Department for Internal Medicine 3, St. Marien-Krankenhaus Siegen, Siegen, Germany

25. 25Department of Hematology, Oncology and Pneumology, University Medical Center, Johannes Gutenberg-University Mainz, Mainz, Germany

26. 26Department of Hematology, Oncology, Rheumatology and Clinical Immunology, Saarland University Medical Center, Homburg, Germany

27. 27Internal Medicine III, Universitätsklinikum Regensburg, Regensburg, Germany

28. 28Department of Hematology, Oncology and Tumor Immunology, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

29. 29University Hospital, Oslo, Norway, Division of Cancer Medicine and Department of Oncology, Oslo, Norway

30. 30Department of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany

31. 31Hematology and CTMO, Azienda Ospedaliera-Universitaria di Parma, Parma, Italy

32. 32Department of Internal Medicine, Holstebro Regional Hospital, Holstebro, Denmark

33. 33Division of Hematology, Azienda Ospedaliera e Universitaria Città della Salute e della Scienza, Torino, Italy

34. 34Department of Hematology, Oncology and Palliative Care, Klinikum Stuttgart, Stuttgart, Germany

35. 35University Hospital of Cologne, Cologne, DEU

36. 36Pathology Unit, San Raffaele Scientific Institute, Milano, Italy

37. 37Lymphoma Unit, Department of Onco-Hematology, IRCCS San Raffaele Scientific Institute, Milano, Italy

38. 38Department of Medical Oncology, University Hospital Basel, Basel, Switzerland

39. 39University Hospital Augsburg, Augsburg, Bay, DEU

40. 40Department of Hematology, Oncology and Stem Cell Transplantation, University Hospital Freiburg, Freiburg im Breisgau, DEU

41. 41Department of Neuroradiology, Klinikum Stuttgart, Stuttgart, Germany

42. 42Department of Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University of Freiburg, Freiburg, Germany

43. 43Center of clinical trials, University Medical Center Freiburg, Freiburg, DEU

44. 44Clinical Trials Unit, University Medical Center Freiburg, Freiburg, Germany

45. 45Clinic of Radiology, Kantonsspital St. Gallen, St. Gallen, Switzerland

46. 46IOSI-Oncology Inst. of Southern Switzerland, Bellinzona, Switzerland

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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