Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children-Reference-Cited by-同舟云学术

Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children

Published:2013-08-01 Issue:5 Volume:122 Page:842-851
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Moxon Christopher A.¹²³,Wassmer Samuel C.⁴,Milner Danny A.⁵,Chisala Ngawina V.¹,Taylor Terrie E.⁶⁷,Seydel Karl B.⁶⁷,Molyneux Malcolm E.¹,Faragher Brian²,Esmon Charles T.⁸⁹,Downey Colin³,Toh Cheng-Hock³,Craig Alister G.²,Heyderman Robert S.¹²

Affiliation:

1. Malawi-Liverpool-Wellcome Clinical Research Programme, University of Malawi College of Medicine, Blantyre, Malawi;

2. Liverpool School of Tropical Medicine, Liverpool, United Kingdom;

3. Liverpool University, Liverpool, United Kingdom

4. New York University School of Medicine, New York, NY;

5. The Brigham and Women's Hospital, Boston, MA;

6. College of Osteopathic Medicine, Michigan State University, East Lansing, MI;

7. Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi;

8. Oklahoma Medical Research Foundation, Oklahoma City, OK;

9. Howard Hughes Medical Institute, Oklahoma City, OK; and

Abstract

Key Points In cerebral malaria, IEs cause loss of protein C receptors and a highly localized microvascular coagulopathy. Low cerebral constitutive expression of these receptors, EPCR and TM, may explain the brain's vulnerability to IE-dependent pathology.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/5/842/1374634/842.pdf

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4. The distribution and intensity of parasite sequestration in comatose Malawian children.;Seydel;J Infect Dis,2006

5. Cerebral malaria pathogenesis: revisiting parasite and host contributions.;Grau;Future Microbiol,2012

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