Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver

Abstract

Key Points Tmod3 deletion leads to reduced erythroid progenitors and impaired erythroblast survival, cell-cycle exit, and enucleation. Erythroblast-macrophage islands are reduced in the absence of Tmod3, which is required in both cell types for island formation.